World Vaccine & Immunotherapy 2020

World Vaccine & Immunotherapy 2020

Please join our oral presentation on, “Broad and Prevalent SARS-CoV-2 CD8+ T Cell Response in Recovered COVID-19 Individuals Demonstrates Kinetics of Early Differentiation” and meet our team.

Session Date: Tuesday, December 1, 2020

Session Time: 4:20 PM PST

Come visit ImmunoScape’s virtual booth at the WVIC 2020, December 1-3, 2020 and chat with us.

CD8+ T cell responses in convalescent COVID-19 individuals target epitopes from the entire SARS-CoV-2 proteome and show kinetics of early differentiation

In this study, using our multiplexed peptide-MHC tetramer approach to screen 408 SARS-CoV-2 candidate epitopes for CD8+ T cell recognition, we identified 52 unique epitope hits (18 unreported), spanning different viral proteins. Insights gained from these SARS-CoV-2 reactivities and their associated T cell profiles capable of differentiating into long-term mediators of protection may guide the rational design of COVID-19 vaccine candidates to curb this pandemic.

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